Our Conclusive -Clinical Study

Supplementation with the Functional Fiber, PolyGlycopleX®, Increases Fecal Short Chain Fatty Acids in Healthy Adults.


PGX® is a highly viscous, functional fibre that increases fecal SCFA concentrations which may play a role in modulating gut satiety hormone secretion and energy balance.


Short chain fatty acids (SCFA) are produced by bacterial fermentation of dietary fibre and have been linked to stimulation of satiety hormones and modulation of serum cholesterol. Our objective was to examine faecal SCFA concentrations in subjects consuming the functional fibre, PolyGlycopleX® (PGX®), or control (skim milk powder) for 3 wk.


54 healthy adults participated in a randomized, double-blind, placebo controlled study. Subjects consumed 5 g/d of PGX or control during the first week followedby 10 g/d in the second and third weeks (n=27/group). The primary outcome was SCFA concentrations in faecal samples collected at baseline (visit 1, V1), at 1 wk (V2),and at 3 wk (V3).


Acetate concentrations were higher with PGX versus control at V3 (P=0.02). There were no differences in propionate, butyrate, valerate or caproate. There was a significant treatment effect (p=0.03) for total SCFA with higher concentrations with PGX versus control. There was a significant negative correlation between propionate and previously measured fasting ghrelin (r= -0.29; P=0.03) at V3.

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