Clinical Study

Meal replacements and fibre supplement as a strategy for weightloss. Proprietary PGX® meal replacement and PGX® fibre supplement in addition to a calorie-restricted diet to achieve weight loss in a clinical setting


Consumption of whey-protein-based meal replacement in conjunction with highly viscous soluble fibre in the form of PGX® can have a significant and beneficial effect on weight loss on overweight and obese participants. Given the worldwide obesity epidemic and the initial positive outcomes obtained in this open clinical programme, the use of PGX® meal replacements (Slim Styles®) and additional PGX® granules along with a controlled dietary intake should be further investigated as a natural solution for short-term and long-term weight management.


The purpose of this study was to determine if PGX® meal replacements (Slim Styles®) and PGX® granules in combination with a calorie-restricted diet would aid in weight loss in a clinical setting.


Fifty-two overweight and obese participants (49 women, 3 men; average age 47.1 years) with a mean body mass index (BMI) of 33.8 ± 6.4 kg/m2 consumed 57 g of proprietary PGX® meal replacement product (Slim Styles®) at breakfast and another 57 g at lunch for 12 weeks. In addition to the meal replacements (Slim Styles®), they were also asked to consume 5 g/day of PGX® in the form of granules, powder or capsules together with 250 ml water. A registered dietician recommended low-fat, low-glycaemic-index foods for snacks and the dinner menus such that each volunteer was consuming a total of 1200 kcal/day.


All participants (n = 52) lost a significant amount of weight from baseline (4.69 ± 3.73 kg), which was further reflected in the reductions in their waist (7.11 ± 6.35 cm) and hip circumference (5.59 ± 3.58 cm) over the 12-week study (p < 0.0001). BMI scores (n = 51) were reduced by 1.6 ± 1.4 kg/m2. The use of PGX® meal replacements and PGX® granules along with a controlled dietary caloric intake is of benefit for short-term weight loss.

Ronald G. Reichert, Raylene A. Reimer, Veronica Kacinik, Sebely Pal, Roland J. Gahler and Simon Wood Biotechnology and Genetic Engineering Reviews, 2013

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