PGX® Lowers Cholesterol
PGX® helps lower "bad" (LDL) cholesterol levels by increasing the excretion rate of blood cholesterol. The liver packages the cholesterol into bile acids and sends them to the small intestine for fat breakdown.
As a highly viscous soluble fibre, PGX® helps lower cholesterol levels by binding to bile acids in the gastrointestinal tract. This action inhibits the reabsorption of bile, increasing its excretion and thereby removing bile from the enterohepatic circulation. A decrease in bile returned to the liver necessitates the use of cholesterol for the synthesis of new bile acids. The net effect of this process is a lowering of serum (total and LDL) cholesterol levels.
Also, in the colon, PGX has been shown to be prebiotic, and may influence gut microbial fermentation producing short-chain fatty acids which are absorbed by the portal circulation and inhibit cholesterol synthesis in the liver.
Research Results: In one published study involving healthy male and female volunteers, a dose of 10 grams of PGX® per day over 21 days was shown to reduce total cholesterol levels by 14% and LDL levels by 17%, respectively4. In males and females with a BMI ranging from 27 to 40, 10 grams of PGX® over 14 weeks was shown to reduce total cholesterol levels by 18% and LDL by 25%5.
Read more about the science of PGX®.